Brief Definitive Report GENETIC CONTROL OF SPECIFIC IMMUNE SUPPRESSION III. Mapping of H-2 Complex Complementing Genes Controlling Immune Suppression by the Random Copolymer L-Glutamic Acid-'°-L-Tyrosine -'° (GT)* BY PATRICE DEBRE, CARL WALTENBAUGH, MARTIN DORF, AND BARUJ BENACERRAF

نویسندگان

  • PATRICE DEBRE
  • CARL WALTENBAUGH
  • MARTIN DORF
  • BARUJ BENACERRAF
چکیده

Ear l ie r studies from our laboratory demonstra ted tha t the terpolymer of L-glutamic acid, L-alanine, and L-tyrosine (GAT) s t imula ted the development of T cells capable of specifically suppressing the antibody responses in vivo and in vitro of nonresponder s t ra ins (bearing the H-2 "~, H-2 q, and H-2" haplotypes) to GAT complexod with an immunogenic carr ier , methyla tod bovine serum albumin, MBSA (1, 2). We then extended these findings to another ant igen, the copolymer of L-glutamic acid and L-tyrosine (GT). None of 19 inbred or congenic res is tant mouse s t ra ins developed antibody responses to GT after immunizat ion with this synthetic polypeptide in adjuvants. All the s t rains investigated, however, developed IgG plaque-forming cells (PFC) p r imary responses to GT complexed with MBSA (3). This permit ted us to determine that: (a) pre immunizat ion with GT suppressed the response to GT-MBSA in certain but not in all strains; (b) the suppression could be t ransferred by thymocytes and spleen cells from GT-primed animals; (c) the development of GT-specific suppressor cells is under dominant control of H2-1inked gene(s) which have been designated specific immune suppressor genes (Is genes); (d) the Is genes are ant igen specific since GAT-MBSA responses are suppressed by GAT in s t ra ins carrying the H-2 q haplotype, while GT-MBSA responses are not suppressed by the re la ted polymer GT in these same strains (3, 4).

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تاریخ انتشار 2003